Restylane and Perlane are both hyaluronic acid fillers made by the same company, QMed. You’ve probably heard of hyaluronic acid, a naturally occuring substance the human body produces that is responsible for giving the skin volume, hydration, and fullness. As we age, our hyaluronic acid production decreases, so our skin becomes more lax and prone to wrinkles and folds. Both of these fillers are injected to fill the space between collagen and elastin fibers within the skin to restore lost volume. They also attract and bind to water molecules to hydrate and fill the injection area.
So, what’s the difference between the two? It turns out Perlane and Restylane are perfect complements to one another.
Perlane is thicker in consistency than Restylane. This is because it is more crosslinked, allowing it to provide longer duration in the tissue. Perlane is three times thicker than Restylane.
Because it is thicker, Perlane needs fat around it to hide the filler. So, it works well adding volume to the cheeks, chin, and nasolabial folds. Moderate to severe folds love Perlane.
Restylane is the more popular filler. It has been used over 11 million times! It is far thinner than Perlane because is has less crosslinking. This allows Restylane to flow, so it is perfect for defining the lip edge or the hollows under the eyes. It works well on sensitive areas with finer wrinkles and thinner skin.
Which lasts longer? Perlane, of course, because its thickness allows it to stay in the tissue longer. Restylane lasts about a year or more; Perlane six months longer than that.